CPL Biotech Research division – drug discovery and developmentwas initiated in 2007 and we are committed to discover and develop Biotechnology novel molecules. Century recognizes the role of Biotechnology as the future of the pharmaceutical industry in enhancing the specificity and effectiveness of such molecules.
Stem Cell Research
Stem Cells and Human Development
Stem cells have tremendous potential for treating disease and replacing or regenerating the diseased tissue. Stem cells have enormous potential in health and medical research but to fully harness this potential, scientists are studying how stem cells transform, or differentiate, into the diverse range of specialized cells that make humans what they are today.
Century pharmaceuticals ltd Biotechnology Research Division started the stem cell research in the year 2014 knowing the study of stem cells is one of the most exciting areas of contemporary biomedical research and believed that Stem Cell Research & Therapy will act as a highly active forum for both basic and translational research into stem cell biology and therapies.
Stem cells have enormous potential for alleviating suffering for many diseases which currently have no effective therapy. Our research has progressed to the preclinical evaluation and it is important that this pathway leading an excellent science and rigorous standards of clinical research to treat age related degenerative and terminal patients.
Stem Cell can cure the following Disease
The most exciting use of stem cells rests on their ability to differentiate into an enormous range of healthy functioning adult cells, thereby providing a replacement source of cells to treat serious diseases possibly. This ultimately means that virtually any disease that result in cellular and tissue destruction.
Stem cell research into heart disease has shown some very promising results. The goal is to eventually replace all of the damaged heart tissue with healthy cells.
People who are diagnosed with type I diabetes have abnormal insulin regulation.
Parkinson’s disease entails the destruction of cells producing a neurotransmitter called dopamine.
Many people may have already heard of bone marrow transplants, which are a type of stem cell transplant that have been used for years now. This type of transplant is used for cancers such as leukaemia.
Spinal Cord Injuries
The potential benefit of stem cell therapy for spinal cord injuries is remarkable in that it may one day reverse what is currently an irreversible condition.
Rheumatoid Arthritis, through the use of stem cells, these procedures helps patients who donâ€™t respond to typical drug treatment.
Stem cells could reduce the need for knee replacement
These non-surgical stem cell injection procedures happen within a single day and may offer a viable alternative for those who are facing surgery or even joint replacement. Patients are typically able to return to normal activity following the procedure and are able to avoid the painful and lengthy rehabilitation periods that are typically required to help restore strength, mobility and range-of-motion following invasive joint surgeries. Lastly, patients are far less vulnerable to the risks of surgeries, such as infection and blood clots.
- Burn victims
- Cardiovascular diseases
Endometrial regeneration using autologous adult stem cells in a patient of severe Asherman’s syndrome – Research attempt
From adult autologous stem cells isolated from patient,s own and endometrial angiogenic stem cells are being separated using immunomagnetic isolation. These cells will be placed in the endometrial cavity under ultrasound guidance. Patient was then given cyclical hormonal therapy. Endometrium was assessed intermittently on ultrasound. On development of endometrium with a thickness of 8 mm and good vascularity, in vitro fertilization and embryo transfer can be done. This research may result in positive biochemical pregnancy followed by confirmation of gestational sac, yolk sac, and embryonic pole with cardiac activity on ultrasound. Endometrial angiogenic stem cells isolated from autologous adult stem cells could regenerate injured endometrium not responding to conventional treatment for Asherman’s syndrome. The research have been conducted with the co operation of Isha hospital under the guidance of Dr. Shilpi Shukla. Thus the stem cells can be used in the treatment of infertility.
GMP Stem Cell Facility
Century Stem cell Research Guiding Principles
- Adherence to GMP regulations as required by the DCGI/FDCA
- Precisely followed Standard Operating Procedure
- Strict Quality Control (QC) and Quality Assurance (QA), with each being done by different individuals
- Testing of final products according to FDA guidance and requirements
- Rigorous personnel training and proficiency testing
- Meticulous documentation and record keeping
- Readiness for audits
GMP STEM Cell Laboratory Goal
- We are the pioneer Indian pharmaceutical company involved in the stem cell research
- The manufacture of quality products for clinical application
- Pass-through results by adopting GMP protocols and regulatory norms of products as expected by Experts and national auditors of DCGI/FDA in the facility audit meeting.
Link to Stem cell research news http://www.stemcellresearchnews.net/Diseases_Treated.aspx
Recombinant rDNA Technology
Recombinant protein is a protein that whose code is carried by a recombinant DNA. The genetically modified bacteria will make protein based on this recombinant DNA. This Recombinant protein are being to treat various diseases. Century has adapted one such technology to treat Asthma and allergy .
The company is involved with the creation of significant biotechnology research capabilities in the area of targeted human therapeutic proteins. The Current status of the project has reached preclinical evaluation. Knowing the superiority of the technology and export market Century has decided to conduct the preclinical activity in aboard on transgenic animals.
This plat form technology has been successfully demonstrated at clinical level make the pavement to develop biomolecules for signal and receptor mediated diseases using this technology like cancer. Human phase-1 clinical trial is expected in 2017.
We are the first SME organization to start this new business model of a â€œResearch Boutiqueâ€.
- Fusion protein
- Mast cell
- Asthma and allergy
- Pledged to develop drug candidates wonâ€™t cause any side effects to the patients like steroids.
New Product development
Vitamin D, as either D3 or D2, does not have significant biological activity. Rather, it must be metabolized within the body to the hormonally-active form known as 1,25-dihydroxycholecalciferol. Bioactive vitamin D or Calcitriol is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. We make the calcitriol through Bioconversion method.
Serratiopeptidase, a proteolytic enzyme with anti-inflammatory activity is widely used in many inflammatory conditions like arthritis, post operative inflammation, dental treatment etc. Serratiopeptidase improves microcirculation and reduces pain by blocking the release of pain inducing amines from inflamed tissues. Increasing importance of serratiopeptidase as a potential anti-inflammatory agent has motivated us produce API to use it in combination with conventional medicines.
Product under development
- Nutritional supplements
- Veterinary Food supplements
Collaborative Research National Collaboration
We believe in innovation. Innovation comes from the young aspirant minds of young students.
Our organization always believes in Industry â€“Academia partnerships.We have signed MOUâ€™s with various organizations like
â€œTarget inâ€ an international organization has transferred the technology and licensed to Century Pharmaceuticals ltd to develop the technology and market.
b. SUMANDEEP UNIVERSITY
c. PARUL UNIVERSITY
e. Fisheries Research Mumbai